Cancer Chemotherapy Chinese Detox Medicine
ydrolysed ergot
alkaloids, to unreacted lysergic acid, or lysergic acid hydrazides to iso-
LSD and God knows what substances created by the mishandling of
the raw materials and product, a contaminated product is much easier to
make than a pure one.
The use of large volumes of solvents poses twin problems:
obtaining them and disposing of them. Both problems are
Nicotinearthritis made vastly
Practical LSD Manufacture
70
simpler by recycling the solvents. Just because a solvent has been
used once in a given stage of the process does not mean its useful
lifetime is over. For example, the solvent used for defatting the crop is
easily made as good as new by distilling it to free it of its load of fat.
Other solvents are not so easily recovered for re-use because the
procedure calls for the given solvent to be removed from the product
by vacuum evaporation. In this case, the solvent can be collected in a
cold trap placed along the vacuum line on its way to the vacuum
source. If a pump
Synthesize Bremelanotide is used to create the vacuum, such a trap is vital to
prevent solvent vapors from getting into the pump oil, thereby ruining
the lubrication and the vacuum created.
A cold trap can be constructed of either glass or steel; it need only be
large enough to hold the solvent collected, and airtight so as not to ruin
the vacuum with leaks. This cold trap is then cooled down with dry ice
during vacuum evaporations to condense the solvent vapors in the trap.
The solvent recovered in the trap can be re-used in the given stage of
the process from whence it came. I would not co-mingle recovered
solvents from different stages. For example, chloroform from the
alkaloid extraction of the crops should be kept for that usage, and not
be used for LSD crystallization, because it will also contain some
ammonia and methanol.
The recovery of ether, for example, from method 2 of lysergic acid
production, poses a special problem.
This problem is the formation of
explosive peroxides in ether during storage. Ether containing water
and alcohol, as would be the case for this recovered solvent, does not
form much peroxide. There is a possibility that dry ether can be made
free of peroxides by shaking the ether with some 5% ferrous sulfate
(FeSO4) solution in water prior to distilling.
Failure to do this may
expose the operator to a fiery explosion during distillation. Ice water
flowing through the condenser, and an ice-chilled receiving flask, are
required to get an efficient condensation of the ether during
distillation.
11
Keeping Out Of Trouble 71
II
Keeping Out Of Trouble
The dangers of LSD manufacturing do not end with the possibility
that the cooker may spill some of the stuff on himself and fry his
brain. There is a much more malignant danger facing those who
embark upon this course: Johnny Law.
The conduit through which those shit-eating dogs travel to get to
you is your associates.
If you are cooking alone with no partners in
crime, your safety has been impro
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The Operation Julie cooker had made the obvious analogy that if
the procedure works for these substances closely related to LSD, it
should also work for LSD. This type of underground research and
discovery is not at all unusual. If you look through the Chem. Abstracts
for references to the use of hydriodic acid and red phosphorus in the
reduction of ephedrine to meth, you will find nothing. This procedure is
a general method of reducing alcohols to alkanes, and was applied by
clandestine chemists to ephedrine with excellent results. Ditto for the
lithium-metal-in-liquid-ammonia reduction of ephedrine to meth.
To get the full details of the following procedure, your command of
Russian or Hungarian had better be firmer than mine. All this research
came out of Eastern Europe. For example, see Chem. Abstracts,
Volume 93, column 186636. This will then direct you to: Otkrytiya,
hobret., Prom. Obraztsy, Tovarnye Znaki 1980, (19), 303. Also Italian
patent application 76/50,746 dating to Dec. 6, 1976.
For this method to be superior to the procedures given in the
earlier chapters of this book, the need for a close stoichiometric
quantity of anhydride added would have to be done away with. It must be
possible to add a healthy excess of the propionic anhydride to get
100% conversion of the lysergic acid to the mixed anhydride. It would
Method X 67
further be nice if the procedure works with the hydrous form of
lysergic acid, doing away with the need to bake it under high vacuum.
Further advances in LSD manufacture taken from analogy to
closely related compounds can also be found in the hydrazide "one-pot
shot" route to LSD. It would appear that lysergic acid hydrazide can
be reacted with the very common chemical sodium nitrite, and then
diethylamine to give LSD. This eliminates the need to synthesize or
otherwise obtain 2,4-pentanedione. (For synthesis of 2,4-
pentanedione, see U.S. Patent 2,737,528 and 2,834,811.) See Chem.
Abstracts Volume 94, column 209051 (1981) and German Patent
2,924,102. Another analogy can be found in Chem. Abstracts Volume
99, column 71069 which then refers you to German Patent DE
3,239,788. It would appear that phosgene, as used in Chapter 8, can be
replaced with oxalyl chloride. This substance is much less
dangerous than phosgene, and more easily measured out.
Preparation of Propionic Anhydride
Propionic anhydride is obviously going to be impossible to
purchase without getting busted. It is, however, not too difficult to
make in good yield and high purity. The simplest method of
preparation is via the general method found on page 28 of Organic
Synthesis Collective Volume 3. In this method propionic acid reacts
with propionyl chloride in the presence of pyridine to yield propionic
anhydride. Propionyl chloride is at present an easily obtained
substance, but in the future, this may change. When that time comes,
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